Assay Detail
Functional
CHEMBL3129239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytostatic activity against human CEM-DNR-bulk cells after 72 hrs by MTT assay
82
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-DNR-bulk |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 82 | 5.80 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269812 | — | — | 1 | 7.30 |
| CHEMBL3126908 | — | — | 1 | 7.16 |
| CHEMBL3126907 | — | — | 1 | 7.00 |
| CHEMBL3127055 | — | — | 1 | 6.96 |
| CHEMBL3127065 | — | — | 1 | 6.80 |
| CHEMBL3126914 | — | — | 1 | 6.80 |
| CHEMBL1814768 | — | — | 1 | 6.77 |
| CHEMBL1814767 | — | — | 1 | 6.68 |
| CHEMBL3127049 | — | — | 1 | 6.64 |
| CHEMBL3126905 | — | — | 1 | 6.62 |
| CHEMBL3126906 | — | — | 1 | 5.58 |
| CHEMBL3126899 | — | — | 1 | 5.50 |
| CHEMBL3127047 | — | — | 1 | 5.46 |
| CHEMBL3126865 | — | — | 1 | 5.46 |
| CHEMBL3127056 | — | — | 1 | 5.44 |
| CHEMBL3126898 | — | — | 1 | 5.31 |
| CHEMBL3126895 | — | — | 1 | 5.20 |
| CHEMBL3127068 | — | — | 1 | 5.12 |
| CHEMBL3126911 | — | — | 1 | 5.07 |
| CHEMBL3127046 | — | — | 1 | 4.97 |
| CHEMBL3127067 | — | — | 1 | 4.92 |
| CHEMBL3126896 | — | — | 1 | 4.90 |
| CHEMBL3126915 | — | — | 1 | 4.90 |
| CHEMBL3126874 | — | — | 1 | 4.82 |
| CHEMBL3126871 | — | — | 1 | 4.78 |
| CHEMBL3127064 | — | — | 1 | 4.73 |
| CHEMBL3126879 | — | — | 1 | - |
| CHEMBL3127066 | — | — | 1 | - |
| CHEMBL3127044 | — | — | 1 | - |
| CHEMBL3126913 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269812 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3126908 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3126907 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3127055 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3127065 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3126914 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1814768 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1814767 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3127049 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3126905 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3126906 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3126899 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL3127047 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL3126865 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL3127056 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL3126898 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL3126895 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL3127068 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL3126911 | — | IC50 | = | 8560.0 | nM | 5.07 |
| CHEMBL3127046 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3127067 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL3126896 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL3126915 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL3126874 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3126871 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL3127064 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL319177 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127051 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127052 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127053 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127054 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127057 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127058 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127059 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127060 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127061 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127062 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127063 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126879 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126900 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126901 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126902 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126903 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126904 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126909 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126910 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126912 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126913 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127044 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127066 | — | IC50 | > | 20000.0 | nM | - |