Assay Detail
Functional
CHEMBL3129240
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Cytostatic activity against human CCRF-CEM cells after 72 hrs by MTT assay
82
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 82 | 5.95 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269812 | — | — | 1 | 8.00 |
| CHEMBL1814768 | — | — | 1 | 7.70 |
| CHEMBL3127065 | — | — | 1 | 7.70 |
| CHEMBL1814767 | — | — | 1 | 7.40 |
| CHEMBL3126908 | — | — | 1 | 7.40 |
| CHEMBL3127049 | — | — | 1 | 7.30 |
| CHEMBL3127067 | — | — | 1 | 7.05 |
| CHEMBL3126905 | — | — | 1 | 7.05 |
| CHEMBL3127066 | — | — | 1 | 6.96 |
| CHEMBL3127058 | — | — | 1 | 6.75 |
| CHEMBL3126906 | — | — | 1 | 6.20 |
| CHEMBL3127048 | — | — | 1 | 5.94 |
| CHEMBL3126907 | — | — | 1 | 5.80 |
| CHEMBL3127068 | — | — | 1 | 5.59 |
| CHEMBL3126899 | — | — | 1 | 5.54 |
| CHEMBL3126902 | — | — | 1 | 5.46 |
| CHEMBL3127046 | — | — | 1 | 5.27 |
| CHEMBL3126915 | — | — | 1 | 5.26 |
| CHEMBL3126914 | — | — | 1 | 5.25 |
| CHEMBL3126865 | — | — | 1 | 5.04 |
| CHEMBL3126880 | — | — | 1 | 5.04 |
| CHEMBL3126911 | — | — | 1 | 4.95 |
| CHEMBL3126871 | — | — | 1 | 4.90 |
| CHEMBL3126900 | — | — | 1 | 4.88 |
| CHEMBL3127050 | — | — | 1 | 4.85 |
| CHEMBL3126881 | — | — | 1 | 4.84 |
| CHEMBL3127044 | — | — | 1 | 4.82 |
| CHEMBL3126913 | — | — | 1 | 4.76 |
| CHEMBL3126874 | — | — | 1 | 4.75 |
| CHEMBL3126904 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269812 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1814768 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3127065 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1814767 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3126908 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3127049 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3127067 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3126905 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3127066 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3127058 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3126906 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3127048 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL3126907 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL3127068 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL3126899 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL3126902 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL3127046 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL3126915 | — | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL3126914 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3126865 | — | IC50 | = | 9030.0 | nM | 5.04 |
| CHEMBL3126880 | — | IC50 | = | 9030.0 | nM | 5.04 |
| CHEMBL3126911 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL3126871 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL3126900 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3127050 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL3126881 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL3127044 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3126913 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL3126874 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL3127045 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127047 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL403715 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127051 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127052 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127053 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127054 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127055 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127056 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127057 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127059 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127060 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127061 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127062 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127063 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127064 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126898 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126901 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126903 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL319177 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126904 | — | IC50 | > | 20000.0 | nM | - |