Assay Detail
Binding
CHEMBL3129508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse HDAC6 expressed in human 293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | 293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.04 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 6.41 |
| CHEMBL1836142 | THAILANDEPSIN A | — | 1 | 6.00 |
| CHEMBL3126833 | — | — | 1 | 5.70 |
| CHEMBL3126831 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1836142 | THAILANDEPSIN A | IC50 | = | 992.0 | nM | 6.00 |
| CHEMBL3126833 | — | IC50 | = | 1975.0 | nM | 5.70 |
| CHEMBL3126831 | — | IC50 | > | 10000.0 | nM | - |