Assay Detail
Functional
CHEMBL3130042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by MTT assay in presence of 10% FBS
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.00 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3126408 | — | — | 1 | 7.89 |
| CHEMBL3126418 | — | — | 1 | 7.57 |
| CHEMBL3126417 | — | — | 1 | 6.50 |
| CHEMBL3126407 | — | — | 1 | 6.02 |
| CHEMBL3126422 | — | — | 1 | - |
| CHEMBL3126419 | — | — | 1 | - |
| CHEMBL3126416 | — | — | 1 | - |
| CHEMBL3126420 | — | — | 1 | - |
| CHEMBL3126425 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3126408 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3126418 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3126417 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3126407 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3126422 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3126419 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3126416 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3126420 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3126425 | — | IC50 | > | 5000.0 | nM | - |