Assay Detail
Functional
CHEMBL3130049
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Antiproliferative activity against human RKO cells assessed as DNA synthesis level after 24 hrs by thymidine incorporation assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RKO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.91 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1221966 | PATEAMINE A | — | 1 | 9.42 |
| CHEMBL3126408 | — | — | 1 | 8.92 |
| CHEMBL3126413 | — | — | 1 | 8.38 |
| CHEMBL3126415 | — | — | 1 | - |
| CHEMBL3126414 | — | — | 1 | - |
| CHEMBL3126412 | — | — | 1 | - |
| CHEMBL3126411 | — | — | 1 | - |
| CHEMBL3126410 | — | — | 1 | - |
| CHEMBL3126409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1221966 | PATEAMINE A | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL3126408 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3126413 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3126415 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3126414 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3126412 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3126411 | — | IC50 | - | — | - | |
| CHEMBL3126410 | — | IC50 | - | — | - | |
| CHEMBL3126409 | — | IC50 | - | — | - |