Assay Detail
Binding
CHEMBL3131102
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Direct binding affinity to free Bcl-XL (unknown origin) assessed as association constant measured for 60 secs by surface plasmon resonance
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.51 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371861 | — | — | 1 | 6.05 |
| CHEMBL3125475 | — | — | 1 | 5.31 |
| CHEMBL3125476 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371861 | — | Kd | = | 900.0 | nM | 6.05 |
| CHEMBL3125475 | — | Kd | = | 4900.0 | nM | 5.31 |
| CHEMBL3125476 | — | Kd | = | 6900.0 | nM | 5.16 |