Assay Detail
Binding
CHEMBL3131191
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Inhibition of human recombinant FBPase expressed in Escherichia coli BL21(DE3) by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coupled assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.10 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3127628 | — | — | 1 | 6.00 |
| CHEMBL31344 | — | — | 1 | 5.70 |
| CHEMBL752 | ADENOSINE PHOSPHATE | 4.0 | 1 | 5.50 |
| CHEMBL3127767 | — | — | 1 | 5.47 |
| CHEMBL3127748 | — | — | 1 | 5.43 |
| CHEMBL3127749 | — | — | 1 | 5.39 |
| CHEMBL3127629 | — | — | 1 | 5.37 |
| CHEMBL3127755 | — | — | 1 | 5.35 |
| CHEMBL3127747 | — | — | 1 | 5.27 |
| CHEMBL3127750 | — | — | 1 | 5.21 |
| CHEMBL3127754 | — | — | 1 | 5.13 |
| CHEMBL3127760 | — | — | 1 | 5.11 |
| CHEMBL3127746 | — | — | 1 | 5.01 |
| CHEMBL3127751 | — | — | 1 | 4.99 |
| CHEMBL3127763 | — | — | 1 | 4.91 |
| CHEMBL3127752 | — | — | 1 | 4.90 |
| CHEMBL3127744 | — | — | 1 | 4.73 |
| CHEMBL3127641 | — | — | 1 | 4.59 |
| CHEMBL3127758 | — | — | 1 | 4.59 |
| CHEMBL3127762 | — | — | 1 | 4.54 |
| CHEMBL3127630 | — | — | 1 | 4.47 |
| CHEMBL3127753 | — | — | 1 | 4.45 |
| CHEMBL3127765 | — | — | 1 | - |
| CHEMBL3127745 | — | — | 1 | - |
| CHEMBL3127743 | — | — | 1 | - |
| CHEMBL3127756 | — | — | 1 | - |
| CHEMBL3127757 | — | — | 1 | - |
| CHEMBL3127759 | — | — | 1 | - |
| CHEMBL3127761 | — | — | 1 | - |
| CHEMBL3127764 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3127628 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL31344 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL752 | ADENOSINE PHOSPHATE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3127767 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3127748 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3127749 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL3127629 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3127755 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3127747 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3127750 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3127754 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3127760 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3127746 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL3127751 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3127763 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL3127752 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL3127744 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL3127641 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL3127758 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL3127762 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL3127630 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL3127753 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL3127631 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127640 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127639 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127638 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127637 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127636 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127635 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127634 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127633 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127632 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127765 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127766 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127642 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127764 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127761 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127759 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127757 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127756 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127743 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3127745 | — | IC50 | > | 50000.0 | nM | - |