Assay Detail
Binding
CHEMBL3131502
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Inhibition of full-length HCV NS3 protease R155K mutant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Achiral pyrazinone-based inhibitors of the hepatitis C virus NS3 protease and drug-resistant variants with elongated substituents directed toward the S2 pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.53 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 7.62 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 7.09 |
| CHEMBL3125634 | — | — | 1 | 6.38 |
| CHEMBL3125635 | — | — | 1 | 5.81 |
| CHEMBL3125620 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL231813 | TELAPREVIR | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL3125634 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL3125635 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL3125620 | — | Ki | = | 1800.0 | nM | 5.75 |