Assay Detail
Binding
CHEMBL3131504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length HCV NS3 protease A156T mutant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Achiral pyrazinone-based inhibitors of the hepatitis C virus NS3 protease and drug-resistant variants with elongated substituents directed toward the S2 pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.21 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 6.92 |
| CHEMBL3125634 | — | — | 1 | 6.77 |
| CHEMBL3125620 | — | — | 1 | 6.13 |
| CHEMBL3125635 | — | — | 1 | 6.03 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3125634 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL3125620 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL3125635 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL231813 | TELAPREVIR | Ki | = | 6100.0 | nM | 5.21 |