Assay Detail
Functional
CHEMBL3132225
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Cytotoxicity against human multidrug-resistant CEM/ADR5000 cells expressing p-glycoprotein by resazurin assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ADR5000 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.22 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3125599 | — | — | 1 | 5.95 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 5.92 |
| CHEMBL470981 | EGONOL | — | 1 | 5.01 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.63 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3125599 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL470981 | EGONOL | IC50 | = | 9780.0 | nM | 5.01 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 23270.0 | nM | 4.63 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 26900.0 | nM | 4.57 |