Assay Detail
Binding
CHEMBL3132513
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IKK-epsilon (unknown origin) using 5FAM-AKELDQGSLCTpSFVGTLQ-NH2 as substrate by microfluidic mobility shift assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (CHEMBL3529) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-ε kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.26 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011933 | — | — | 1 | 7.68 |
| CHEMBL3125721 | — | — | 1 | 7.38 |
| CHEMBL2011936 | — | — | 1 | 7.12 |
| CHEMBL3125741 | — | — | 1 | 6.94 |
| CHEMBL3125722 | — | — | 1 | 6.80 |
| CHEMBL3125732 | — | — | 1 | 6.69 |
| CHEMBL3125727 | — | — | 1 | 6.56 |
| CHEMBL3125730 | — | — | 1 | 6.48 |
| CHEMBL3125739 | — | — | 1 | 6.40 |
| CHEMBL3125731 | — | — | 1 | 6.38 |
| CHEMBL3125723 | — | — | 1 | 6.35 |
| CHEMBL373751 | GSK-319347A | — | 1 | 6.33 |
| CHEMBL3125726 | — | — | 1 | 6.30 |
| CHEMBL3125738 | — | — | 1 | 6.06 |
| CHEMBL3125724 | — | — | 1 | 5.96 |
| CHEMBL3125729 | — | — | 1 | 5.96 |
| CHEMBL3125728 | — | — | 1 | 5.76 |
| CHEMBL3125733 | — | — | 1 | 5.59 |
| CHEMBL3125720 | — | — | 1 | 5.49 |
| CHEMBL3125737 | — | — | 1 | 5.48 |
| CHEMBL3125734 | — | — | 1 | 5.17 |
| CHEMBL3125740 | — | — | 1 | 4.94 |
| CHEMBL3125742 | — | — | 1 | - |
| CHEMBL3125725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011933 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3125721 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2011936 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3125741 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL3125722 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL3125732 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL3125727 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL3125730 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3125739 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL3125731 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL3125723 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL373751 | GSK-319347A | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL3125726 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL3125738 | — | IC50 | = | 867.0 | nM | 6.06 |
| CHEMBL3125724 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3125729 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL3125728 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL3125733 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL3125720 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL3125737 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3125734 | — | IC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL3125740 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3125742 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3125725 | — | IC50 | > | 30000.0 | nM | - |