Assay Detail
Binding
CHEMBL3134976
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Inhibition of Norwalk virus recombinant His6-tagged protease using EDANS-EPDFHLQGPEDLAK-Dabcyl as substrate preincubated for 45 mins followed by substrate addition measured every 1 min for 30 mins by FRET analysis
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Norwalk virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.76 | 7.12 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3134264 | — | — | 1 | 7.12 |
| CHEMBL419332 | — | — | 1 | 6.92 |
| CHEMBL3134256 | — | — | 1 | 6.51 |
| CHEMBL3134254 | — | — | 1 | 6.23 |
| CHEMBL3134263 | — | — | 1 | 5.85 |
| CHEMBL95007 | — | — | 1 | 5.82 |
| CHEMBL3134258 | — | — | 1 | 5.80 |
| CHEMBL3134255 | — | — | 1 | 5.72 |
| CHEMBL3134262 | — | — | 1 | 5.29 |
| CHEMBL3134257 | — | — | 1 | 5.09 |
| CHEMBL3134260 | — | — | 1 | 4.41 |
| CHEMBL3134259 | — | — | 1 | 4.34 |
| CHEMBL94557 | — | — | 1 | - |
| CHEMBL19648 | — | — | 1 | - |
| CHEMBL20668 | — | — | 1 | - |
| CHEMBL3134261 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3134264 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL419332 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3134256 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL3134254 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL3134263 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL95007 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3134258 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3134255 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL3134262 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL3134257 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL3134260 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL3134259 | — | Ki | = | 46000.0 | nM | 4.34 |
| CHEMBL94557 | — | Inhibition | - | % | - | |
| CHEMBL19648 | — | Inhibition | - | % | - | |
| CHEMBL20668 | — | Inhibition | - | % | - | |
| CHEMBL3134261 | — | Ki | = | 150000.0 | nM | - |