Assay Detail
Functional
CHEMBL3135040
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Antiprotozoal activity against chloroquine-resistant Plasmodium falciparum C2B assessed as growth inhibition after 72 hrs by SYBR Green dye-based fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.74 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514409 | HESPERADIN | — | 1 | 7.85 |
| CHEMBL3134087 | — | — | 1 | 7.25 |
| CHEMBL3134086 | — | — | 1 | 7.09 |
| CHEMBL3134093 | — | — | 1 | 6.93 |
| CHEMBL3134090 | — | — | 1 | 6.84 |
| CHEMBL3134091 | — | — | 1 | 6.83 |
| CHEMBL500435 | — | — | 1 | 6.80 |
| CHEMBL3134088 | — | — | 1 | 6.76 |
| CHEMBL3134005 | — | — | 1 | 6.76 |
| CHEMBL3134004 | — | — | 1 | 6.68 |
| CHEMBL3134003 | — | — | 1 | 6.60 |
| CHEMBL3134096 | — | — | 1 | 6.13 |
| CHEMBL3134089 | — | — | 1 | 5.97 |
| CHEMBL3134094 | — | — | 1 | 5.80 |
| CHEMBL3134095 | — | — | 1 | - |
| CHEMBL3134092 | — | — | 1 | - |
| CHEMBL3134085 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514409 | HESPERADIN | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3134087 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3134086 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3134093 | — | EC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3134090 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL3134091 | — | EC50 | = | 148.0 | nM | 6.83 |
| CHEMBL500435 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3134088 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL3134005 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL3134004 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3134003 | — | EC50 | = | 249.0 | nM | 6.60 |
| CHEMBL3134096 | — | EC50 | = | 735.0 | nM | 6.13 |
| CHEMBL3134089 | — | EC50 | = | 1062.0 | nM | 5.97 |
| CHEMBL3134094 | — | EC50 | = | 1571.0 | nM | 5.80 |
| CHEMBL3134095 | — | EC50 | - | — | - | |
| CHEMBL3134092 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL3134085 | — | EC50 | - | — | - |