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Compound Detail

CHEMBL3134005

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Nc1ccc2c(c1)/C(=C(/Nc1ccc(CN3CCCCC3)cc1)c1ccccc1)C(=O)N2

Basic Information

ChEMBL ID CHEMBL3134005
Phase Preclinical
Structure Type MOL
InChI Key MVAZIRAADYQTCT-QPLCGJKRSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

424.6
MW (Da)
5.19
ALogP
4
HBA
3
HBD
70.4
PSA (Ų)
0.39
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H28N4O
MW 424.55
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -0.76

Activity Summary

EC50 6 meas. best 6.76

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Plasmodium falciparum
CHEMBL364
EC50 6.76 6.7125 175.0 4
Leishmania major
CHEMBL612879
EC50 6.1 6.1 790.0 1
Trypanosoma brucei
CHEMBL612849
EC50 5.94 5.94 1160.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24910766 10.1039/c4md00045e Plasmodium falciparum 4
24910766 10.1039/c4md00045e Leishmania major 2
24910766 10.1039/c4md00045e HepG2 1
24910766 10.1039/c4md00045e Trypanosoma brucei 1

Data from ChEMBL 36 via Core Engine