Assay Detail
Functional
CHEMBL3135047
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Antiprotozoal activity against promastigote stage of Leishmania major assessed as growth inhibition after 44 hrs by AlamarBlue staining-based fluorescence assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.99 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514409 | HESPERADIN | — | 1 | 6.92 |
| CHEMBL3134085 | — | — | 1 | 6.41 |
| CHEMBL3134096 | — | — | 1 | 6.21 |
| CHEMBL500435 | — | — | 1 | 6.11 |
| CHEMBL3134005 | — | — | 1 | 6.10 |
| CHEMBL3134086 | — | — | 1 | 6.07 |
| CHEMBL3134095 | — | — | 1 | 6.03 |
| CHEMBL3134003 | — | — | 1 | 5.97 |
| CHEMBL3134087 | — | — | 1 | 5.82 |
| CHEMBL3134091 | — | — | 1 | 5.58 |
| CHEMBL3134094 | — | — | 1 | 5.58 |
| CHEMBL3134088 | — | — | 1 | 5.56 |
| CHEMBL3134090 | — | — | 1 | 5.55 |
| CHEMBL3134093 | — | — | 1 | - |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | - |
| CHEMBL402548 | DANUSERTIB | 2.0 | 1 | - |
| CHEMBL3134004 | — | — | 1 | - |
| CHEMBL3134089 | — | — | 1 | - |
| CHEMBL3134092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514409 | HESPERADIN | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3134085 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3134096 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL500435 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3134005 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3134086 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3134095 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3134003 | — | EC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL3134087 | — | EC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL3134091 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3134094 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3134088 | — | EC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL3134090 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3134093 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL572878 | TOZASERTIB | EC50 | > | 21000.0 | nM | - |
| CHEMBL402548 | DANUSERTIB | EC50 | > | 21000.0 | nM | - |
| CHEMBL3134004 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL3134089 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL3134092 | — | EC50 | > | 4000.0 | nM | - |