Assay Detail
Functional
CHEMBL3135041
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Antiprotozoal activity against chloroquine-resistant Plasmodium falciparum W2 assessed as growth inhibition after 72 hrs by SYBR Green dye-based fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.64 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514409 | HESPERADIN | — | 1 | 7.68 |
| CHEMBL3134095 | — | — | 1 | 7.11 |
| CHEMBL3134085 | — | — | 1 | 7.07 |
| CHEMBL3134087 | — | — | 1 | 7.06 |
| CHEMBL3134093 | — | — | 1 | 6.84 |
| CHEMBL3134086 | — | — | 1 | 6.84 |
| CHEMBL3134091 | — | — | 1 | 6.66 |
| CHEMBL3134005 | — | — | 1 | 6.64 |
| CHEMBL3134004 | — | — | 1 | 6.62 |
| CHEMBL500435 | — | — | 1 | 6.56 |
| CHEMBL3134088 | — | — | 1 | 6.56 |
| CHEMBL3134003 | — | — | 1 | 6.51 |
| CHEMBL3134090 | — | — | 1 | 6.46 |
| CHEMBL3134096 | — | — | 1 | 6.08 |
| CHEMBL3134089 | — | — | 1 | 5.90 |
| CHEMBL3134094 | — | — | 1 | 5.60 |
| CHEMBL3134092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514409 | HESPERADIN | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3134095 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3134085 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3134087 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3134093 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL3134086 | — | EC50 | = | 144.0 | nM | 6.84 |
| CHEMBL3134091 | — | EC50 | = | 217.0 | nM | 6.66 |
| CHEMBL3134005 | — | EC50 | = | 228.0 | nM | 6.64 |
| CHEMBL3134004 | — | EC50 | = | 241.0 | nM | 6.62 |
| CHEMBL500435 | — | EC50 | = | 273.0 | nM | 6.56 |
| CHEMBL3134088 | — | EC50 | = | 273.0 | nM | 6.56 |
| CHEMBL3134003 | — | EC50 | = | 307.0 | nM | 6.51 |
| CHEMBL3134090 | — | EC50 | = | 347.0 | nM | 6.46 |
| CHEMBL3134096 | — | EC50 | = | 832.0 | nM | 6.08 |
| CHEMBL3134089 | — | EC50 | = | 1255.0 | nM | 5.90 |
| CHEMBL3134094 | — | EC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL3134092 | — | EC50 | > | 15000.0 | nM | - |