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Assay Detail

CHEMBL3135049

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiprotozoal activity against Trypanosoma brucei 427 assessed as growth inhibition after 48 hrs by PrestoBlue-based fluorescence assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei (CHEMBL612849)
Type ORGANISM
Organism Trypanosoma brucei

Publication

Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery.
Patel G, Roncal NE, Lee PJ, Leed SE, Erath J, Rodriguez A, Sciotti RJ, Pollastri MP.
Medchemcomm (2014) 5 : 655 -658
PubMed 24910766 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 6.36 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3134086 1 8.00
CHEMBL3134085 1 7.70
CHEMBL514409 HESPERADIN 1 7.22
CHEMBL500435 1 7.16
CHEMBL3134095 1 7.00
CHEMBL3134003 1 6.89
CHEMBL3134087 1 6.82
CHEMBL3134094 1 6.43
CHEMBL3134005 1 5.94
CHEMBL3134088 1 5.88
CHEMBL3134093 1 5.84
CHEMBL3134096 1 5.82
CHEMBL3134091 1 5.78
CHEMBL3134090 1 5.75
CHEMBL3134004 1 5.49
CHEMBL3134089 1 5.47
CHEMBL572878 TOZASERTIB 2.0 1 5.00
CHEMBL3134092 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3134086 EC50 = 10.0 nM 8.00
CHEMBL3134085 EC50 = 20.0 nM 7.70
CHEMBL514409 HESPERADIN EC50 = 60.0 nM 7.22
CHEMBL500435 EC50 = 70.0 nM 7.16
CHEMBL3134095 EC50 = 100.0 nM 7.00
CHEMBL3134003 EC50 = 130.0 nM 6.89
CHEMBL3134087 EC50 = 150.0 nM 6.82
CHEMBL3134094 EC50 = 370.0 nM 6.43
CHEMBL3134005 EC50 = 1160.0 nM 5.94
CHEMBL3134088 EC50 = 1320.0 nM 5.88
CHEMBL3134093 EC50 = 1440.0 nM 5.84
CHEMBL3134096 EC50 = 1530.0 nM 5.82
CHEMBL3134091 EC50 = 1670.0 nM 5.78
CHEMBL3134090 EC50 = 1790.0 nM 5.75
CHEMBL3134004 EC50 = 3250.0 nM 5.49
CHEMBL3134089 EC50 = 3360.0 nM 5.47
CHEMBL572878 TOZASERTIB EC50 = 10000.0 nM 5.00
CHEMBL3134092 EC50 > 50000.0 nM -