Assay Detail

CHEMBL3135204

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Functional

Antiproliferative activity against mouse medulloblastoma cells expressing wild type SMO

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

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Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	Medulloblastoma cell
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Hedgehog signalling pathway inhibitors as cancer suppressing agents

Trinh TN, McLaughlin EA, Gordon CP, McCluskey A
Medchemcomm (2014) 5 : 117 -133
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.26	7.26

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL64391	ITRACONAZOLE	4.0	1	7.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL64391	ITRACONAZOLE	IC50	=	55.0	nM	7.26