Assay Detail
Binding
CHEMBL3135819
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Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresis
22
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.46 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3134416 | — | — | 2 | 4.46 |
| CHEMBL69367 | — | — | 1 | - |
| CHEMBL3134412 | — | — | 1 | - |
| CHEMBL3134411 | — | — | 1 | - |
| CHEMBL3134410 | — | — | 1 | - |
| CHEMBL3134409 | — | — | 1 | - |
| CHEMBL3134408 | — | — | 1 | - |
| CHEMBL3134407 | — | — | 1 | - |
| CHEMBL3134406 | — | — | 1 | - |
| CHEMBL1739417 | — | — | 1 | - |
| CHEMBL3134405 | — | — | 1 | - |
| CHEMBL3134413 | — | — | 1 | - |
| CHEMBL3134420 | — | — | 1 | - |
| CHEMBL3134417 | — | — | 1 | - |
| CHEMBL3134415 | — | — | 1 | - |
| CHEMBL3134414 | — | — | 1 | - |
| CHEMBL3134404 | — | — | 1 | - |
| CHEMBL3134421 | — | — | 1 | - |
| CHEMBL3134418 | — | — | 1 | - |
| CHEMBL3134419 | — | — | 1 | - |
| CHEMBL25202 | TAMIBAROTENE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3134416 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3134416 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3134412 | — | IC50 | - | — | - | |
| CHEMBL3134411 | — | IC50 | - | — | - | |
| CHEMBL3134410 | — | IC50 | - | — | - | |
| CHEMBL3134409 | — | IC50 | - | — | - | |
| CHEMBL3134408 | — | IC50 | - | — | - | |
| CHEMBL3134407 | — | IC50 | - | — | - | |
| CHEMBL3134406 | — | IC50 | - | — | - | |
| CHEMBL1739417 | — | IC50 | - | — | - | |
| CHEMBL3134405 | — | IC50 | - | — | - | |
| CHEMBL25202 | TAMIBAROTENE | IC50 | - | — | - | |
| CHEMBL3134413 | — | IC50 | - | — | - | |
| CHEMBL3134420 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3134417 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3134415 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3134414 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3134404 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL3134421 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL3134418 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL3134419 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL69367 | — | IC50 | - | — | - |