Assay Detail
Binding
CHEMBL3135973
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Inhibition of factor 10a (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Transformation of a selective factor Xa inhibitor rivaroxaban into a dual factor Xa/thrombin inhibitor by modification of the morpholin-3-one moiety
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.87 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198362 | RIVAROXABAN | 4.0 | 1 | 9.15 |
| CHEMBL3091516 | — | — | 1 | 7.82 |
| CHEMBL256941 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198362 | RIVAROXABAN | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3091516 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL256941 | — | Ki | = | 230.0 | nM | 6.64 |