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Assay Detail

CHEMBL3136003

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition triglyceride synthesis in rat by oral lipid tolerance test
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Autocuration

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Optimisation of biphenyl acetic acid inhibitors of diacylglycerol acetyl transferase 1 the discovery of AZD2353
Waring MJ, Birch AM, Birtles S, Buckett LK, Butlin RJ, Campbell L, Gutierrez PM, Kemmitt PD, Leach AG, MacFaul PA, O'Donnell C, Turnbull AV
Medchemcomm (2013) 4 : 159 -164
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 9.30 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3133093 1 9.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3133093 IC50 = 0.5012 nM 9.30