Assay Detail
Functional
CHEMBL3136327
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Cytotoxicity against human Raji cells assessed as inhibition of cell proliferation after 3 days by coulter counter analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An integrated approach to the discovery of potent agelastatin A analogues for brain tumors: chemical synthesis and biological, physicochemical and CNS pharmacokinetic analyses
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.24 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096256 | AGELASTATIN A | — | 1 | 6.85 |
| CHEMBL3133723 | — | — | 1 | 6.75 |
| CHEMBL3133724 | — | — | 1 | 6.52 |
| CHEMBL3133728 | — | — | 1 | 6.40 |
| CHEMBL3133725 | — | — | 1 | 6.21 |
| CHEMBL3133721 | — | — | 1 | 5.50 |
| CHEMBL3133729 | — | — | 1 | 5.42 |
| CHEMBL3133718 | — | — | 1 | - |
| CHEMBL3133717 | — | — | 1 | - |
| CHEMBL3133730 | — | — | 1 | - |
| CHEMBL3133727 | — | — | 1 | - |
| CHEMBL3133726 | — | — | 1 | - |
| CHEMBL3133722 | — | — | 1 | - |
| CHEMBL3133720 | — | — | 1 | - |
| CHEMBL3133719 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096256 | AGELASTATIN A | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3133723 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3133724 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3133728 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3133725 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3133721 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL3133729 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3133718 | — | IC50 | - | — | - | |
| CHEMBL3133717 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133730 | — | IC50 | - | — | - | |
| CHEMBL3133727 | — | IC50 | - | — | - | |
| CHEMBL3133726 | — | IC50 | - | — | - | |
| CHEMBL3133722 | — | IC50 | - | — | - | |
| CHEMBL3133720 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133719 | — | IC50 | > | 10000.0 | nM | - |