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Assay Detail

CHEMBL3136473

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimicrobial activity against Plasmodium falciparum W2 after 72 hrs by LDH activity assay
26
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Meridianin G and its analogs as antimalarial agents
Bharate SB, Yadav RR, Khan SI, Tekwani BL, Jacob MR, Khan IA, Vishwakarma RA
Medchemcomm (2013) 4 : 1042 -1048
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.20 6.14
Activity 4 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 6.14
CHEMBL3133764 1 5.51
CHEMBL3133768 1 5.40
CHEMBL48082 1 5.35
CHEMBL3133767 1 5.34
CHEMBL3133773 1 5.00
CHEMBL3133774 1 4.96
CHEMBL3133775 1 4.94
CHEMBL44541 MERIDIANIN C 1 4.93
CHEMBL3133765 1 4.84
CHEMBL3133771 1 4.84
CHEMBL3133777 1 -
CHEMBL3133776 1 -
CHEMBL269671 ARTEMISININ 3.0 1 -
CHEMBL55 PENTAMIDINE 4.0 1 -
CHEMBL267345 AMPHOTERICIN B 4.0 1 -
CHEMBL3133772 1 -
CHEMBL3133778 1 -
CHEMBL3133769 1 -
CHEMBL53463 DOXORUBICIN 4.0 1 -
CHEMBL3133762 1 -
CHEMBL3133766 1 -
CHEMBL3133761 1 -
CHEMBL3133760 1 -
CHEMBL3133759 1 -
CHEMBL3133770 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 720.0 nM 6.14
CHEMBL3133764 IC50 = 3080.0 nM 5.51
CHEMBL3133768 IC50 = 3980.0 nM 5.40
CHEMBL48082 IC50 = 4440.0 nM 5.35
CHEMBL3133767 IC50 = 4580.0 nM 5.34
CHEMBL3133773 IC50 = 10060.0 nM 5.00
CHEMBL3133774 IC50 = 10950.0 nM 4.96
CHEMBL3133775 IC50 = 11600.0 nM 4.94
CHEMBL44541 MERIDIANIN C IC50 = 11670.0 nM 4.93
CHEMBL3133765 IC50 = 14490.0 nM 4.84
CHEMBL3133771 IC50 = 14550.0 nM 4.84
CHEMBL3133777 IC50 - -
CHEMBL3133776 IC50 - -
CHEMBL269671 ARTEMISININ IC50 < 90.0 nM -
CHEMBL55 PENTAMIDINE IC50 - -
CHEMBL267345 AMPHOTERICIN B IC50 - -
CHEMBL3133772 IC50 - -
CHEMBL3133778 IC50 - -
CHEMBL3133769 IC50 - -
CHEMBL53463 DOXORUBICIN IC50 - -
CHEMBL3133762 Activity - -
CHEMBL3133766 IC50 - -
CHEMBL3133761 Activity - -
CHEMBL3133760 Activity - -
CHEMBL3133759 Activity - -
CHEMBL3133770 IC50 - -