Compound Detail
CHEMBL3133768
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Basic Information
| ChEMBL ID | CHEMBL3133768 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GJCBPZBQMNLFPA-UHFFFAOYSA-N |
3
Targets
7
Activities
1
Assay Types
0
PK Parameters
14
Publications
0
Known Names
Molecular Properties
393.2
MW (Da)
4.13
ALogP
5
HBA
1
HBD
73.8
PSA (Ų)
0.56
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 6.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | IC50 | 6.08 | 6.08 | 830.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.4 | 5.265 | 3980.0 | 4 |
| Cryptococcus neoformans CHEMBL365 | IC50 | 4.61 | 4.61 | 24300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 830.0 | nM | 6.08 | Inhibition of Dyrk1A (unknown origin) using Woodtide as substrate after 30 mins ... | 26048785 |
| Plasmodium falciparum | IC50 | = | 3980.0 | nM | 5.4 | Antimicrobial activity against Plasmodium falciparum W2 after 72 hrs by LDH acti... | - |
| Plasmodium falciparum | IC50 | = | 3981.07 | nM | 5.4 | Antiplasmodial activity against Plasmodium falciparum W2 infected in human RBC a... | 26005918 |
| Plasmodium falciparum | IC50 | = | 7450.0 | nM | 5.13 | Antimicrobial activity against Plasmodium falciparum D6 after 72 hrs by LDH acti... | - |
| Plasmodium falciparum | IC50 | = | 7447.32 | nM | 5.13 | Antiplasmodial activity against Plasmodium falciparum D6 infected in human RBC a... | 26005918 |
| Cryptococcus neoformans | IC50 | = | 24300.0 | nM | 4.61 | Antimicrobial activity against Cryptococcus neoformans by NCCLS method | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1039/C3MD00097D | Staphylococcus aureus | 6 |
| - | 10.1039/C3MD00097D | Unchecked | 6 |
| 26048785 | 10.1016/j.bmcl.2015.05.034 | SH-SY5Y | 4 |
| - | 10.1039/C3MD00097D | Cryptococcus neoformans | 3 |
| - | 10.1039/C3MD00097D | Plasmodium falciparum | 2 |
| 26005918 | 10.1016/j.ejmech.2015.05.020 | Plasmodium falciparum | 2 |
| 26048785 | 10.1016/j.bmcl.2015.05.034 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2 |
| - | 10.1039/C3MD00097D | Aspergillus fumigatus | 1 |
| - | 10.1039/C3MD00097D | Candida albicans | 1 |
| - | 10.1039/C3MD00097D | Leishmania donovani | 1 |
| - | 10.1039/C3MD00097D | LLC-PK1 | 1 |
| - | 10.1039/C3MD00097D | Vero | 1 |
| - | 10.1039/C3MD00097D | HepG2 | 1 |
| 26005918 | 10.1016/j.ejmech.2015.05.020 | Mycobacterium tuberculosis | 1 |
Data from ChEMBL 36 via Core Engine