Assay Detail
Binding
CHEMBL3136540
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Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells after 24 hrs by Steady-Glo luciferase reporter gene assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The A-CD analogue of 16,17-estriol is a potent and highly selective estrogen receptor agonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.26 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 10.00 |
| CHEMBL193482 | ESTRIOL | 4.0 | 1 | 8.70 |
| CHEMBL3134122 | — | — | 1 | 7.50 |
| CHEMBL3134123 | — | — | 1 | 5.10 |
| CHEMBL3134124 | — | — | 1 | 5.00 |
| CHEMBL1651148 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL193482 | ESTRIOL | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL3134122 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3134123 | — | EC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL3134124 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1651148 | — | EC50 | > | 10000.0 | nM | - |