Assay Detail

CHEMBL3137181

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Binding

Inhibition of human recombinant CYP1B1 expressed in Escherichia coli by 7-ethoxyresorufin-O-deethylation-based spectrofluorimetry

ChEMBL ↗

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Target

Cytochrome P450 1B1 (CHEMBL4878) ↗

Open DB target context

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Cytochrome P450 1B1 (CHEMBL4878) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cytochrome P450 1B1

CHEMBL4878

Anchored from Assay target.

Protein identity Cytochrome P450 1B1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cytochrome P450 1B1 (CHEMBL4878) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

3,4,2-Trimethoxy-trans-stilbene a potent CYP1B1 inhibitor

Mikstacka R, Wierzchowski M, Dutkiewicz Z, Gielara-Korzanska A, Korzanski A, Teubert A, Sobiak S, Baer-Dubowska W
Medchemcomm (2014) 5 : 496 -501
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.75	8.75

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3132932	—	—	1	8.75

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3132932	—	IC50	=	1.77	nM	8.75