Assay Detail
Binding
CHEMBL3137184
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Inhibition of human recombinant CYP1B1 after 15 mins by 7-ethoxyresorufin-O-deethylation-based spectrofluorimetry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3,4,2-Trimethoxy-trans-stilbene a potent CYP1B1 inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.30 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3132924 | — | — | 1 | 8.40 |
| CHEMBL3132926 | — | — | 1 | 6.68 |
| CHEMBL3132931 | — | — | 1 | 6.52 |
| CHEMBL327223 | — | — | 1 | 6.52 |
| CHEMBL3132928 | — | — | 1 | 6.51 |
| CHEMBL3132925 | — | — | 1 | 6.43 |
| CHEMBL3132927 | — | — | 1 | 6.21 |
| CHEMBL291501 | RESVERATROL 4'-METHYL ETHER | — | 1 | 6.10 |
| CHEMBL83527 | PTEROSTILBENE | 2.0 | 1 | 5.85 |
| CHEMBL498917 | — | — | 1 | 5.68 |
| CHEMBL3132929 | — | — | 1 | 5.38 |
| CHEMBL3132930 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3132924 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3132926 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3132931 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL327223 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3132928 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3132925 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3132927 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL291501 | RESVERATROL 4'-METHYL ETHER | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL83527 | PTEROSTILBENE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL498917 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3132929 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL3132930 | — | IC50 | = | 4440.0 | nM | 5.35 |