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Assay Detail

CHEMBL3137404

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
DNDI: Cytotoxicity against L-6 rat myoblasts from skeletal muscle
40
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Rattus norvegicus
Tissue Muscle tissue
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

DNDi T. cruzi fenarimol series dataset from which preclinical candidate EPL-BS1246 was identified (see also related datasets CHEMBL2448688 and CHEMBL3137440)
Martine Keenan, Paul W. Alexander, Jason H Chaplin, Michael J Abbott, Hugo Diao, Zhisen Wang, Wayne M Best, Catherine J Perez, Scott MJ Cornwall, Sarah K Keatley, RC Andrew Thompson, Susan A Charman, Karen L White, Eileen Ryan, Gong Chen, Jean-Robert Ioset, Thomas W von Geldern, Eric Chatelain

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 4.23 4.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3104376 2 4.42
CHEMBL3104484 1 4.29
CHEMBL3137392 1 4.29
CHEMBL3137391 1 4.28
CHEMBL3137394 1 4.27
CHEMBL3104485 3 4.26
CHEMBL3104488 3 4.24
CHEMBL3104486 3 4.22
CHEMBL3104490 3 4.21
CHEMBL3104489 4 4.16
CHEMBL3137387 1 -
CHEMBL3104374 4 -
CHEMBL3104487 3 -
CHEMBL3137388 1 -
CHEMBL3137389 3 -
CHEMBL3137390 1 -
CHEMBL3137393 1 -
CHEMBL3104480 1 -
CHEMBL3104481 1 -
CHEMBL3104482 1 -
CHEMBL3104483 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3104376 IC50 = 37710.0 nM 4.42
CHEMBL3104376 IC50 = 42420.0 nM 4.37
CHEMBL3104484 IC50 = 51560.0 nM 4.29
CHEMBL3137392 IC50 = 51280.0 nM 4.29
CHEMBL3137391 IC50 = 52510.0 nM 4.28
CHEMBL3137394 IC50 = 54190.0 nM 4.27
CHEMBL3104485 IC50 = 54660.0 nM 4.26
CHEMBL3104485 IC50 = 58220.0 nM 4.24
CHEMBL3104488 IC50 = 56980.0 nM 4.24
CHEMBL3104488 IC50 = 59320.0 nM 4.23
CHEMBL3104486 IC50 = 60880.0 nM 4.22
CHEMBL3104486 IC50 = 61050.0 nM 4.21
CHEMBL3104490 IC50 = 61470.0 nM 4.21
CHEMBL3104488 IC50 = 64590.0 nM 4.19
CHEMBL3104486 IC50 = 66780.0 nM 4.17
CHEMBL3104489 IC50 = 68970.0 nM 4.16
CHEMBL3104489 IC50 = 68970.0 nM 4.16
CHEMBL3104485 IC50 = 73770.0 nM 4.13
CHEMBL3104489 IC50 = 78740.0 nM 4.10
CHEMBL3104487 IC50 > 100000.0 nM -
CHEMBL3104490 IC50 > 100000.0 nM -
CHEMBL3104487 IC50 > 100000.0 nM -
CHEMBL3137388 IC50 > 100000.0 nM -
CHEMBL3104489 IC50 > 100000.0 nM -
CHEMBL3104374 IC50 > 100000.0 nM -
CHEMBL3104374 IC50 > 100000.0 nM -
CHEMBL3137389 IC50 > 100000.0 nM -
CHEMBL3104487 IC50 > 100000.0 nM -
CHEMBL3137389 IC50 > 100000.0 nM -
CHEMBL3137390 IC50 > 100000.0 nM -
CHEMBL3104490 IC50 > 100000.0 nM -
CHEMBL3104374 IC50 > 100000.0 nM -
CHEMBL3137393 IC50 > 100000.0 nM -
CHEMBL3104480 IC50 > 100000.0 nM -
CHEMBL3104481 IC50 > 100000.0 nM -
CHEMBL3104374 IC50 > 100000.0 nM -
CHEMBL3137387 IC50 > 100000.0 nM -
CHEMBL3104482 IC50 > 100000.0 nM -
CHEMBL3104483 IC50 > 100000.0 nM -
CHEMBL3137389 IC50 > 100000.0 nM -