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Assay Detail

CHEMBL3137494

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
DNDI: CYP Inhibition
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cytochrome P450 2C19 (CHEMBL3622)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

DNDi T. cruzi fenarimol series dataset from which preclinical candidate EPL-BS0967 was identified (see also related datasets: CHEMBL3137386 and CHEMBL2448688)
Martine Keenan, Paul W. Alexander, Jason H Chaplin, Michael J Abbott, Hugo Diao, Zhisen Wang, Wayne M Best, Catherine J Perez, Scott MJ Cornwall, Sarah K Keatley, RC Andrew Thompson, Susan A Charman, Karen L White, Eileen Ryan, Gong Chen, Jean-Robert Ioset, Thomas W von Geldern, Eric Chatelain

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.01 5.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3104375 1 5.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3104375 IC50 = 9800.0 nM 5.01