Assay Detail
Binding
CHEMBL3215171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PubChem BioAssay. QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM17. (Class of assay: confirmatory)
248
Total Activities
248
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Category | confirmatory |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 248 | 4.94 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 7.94 |
| CHEMBL67311 | — | — | 1 | 5.45 |
| CHEMBL1898395 | — | — | 1 | 5.43 |
| CHEMBL1527031 | — | — | 1 | 5.42 |
| CHEMBL1329279 | — | — | 1 | 5.24 |
| CHEMBL1605988 | — | — | 1 | 4.96 |
| CHEMBL1494390 | — | — | 1 | 4.94 |
| CHEMBL1503729 | — | — | 1 | 4.77 |
| CHEMBL1896544 | — | — | 1 | 4.73 |
| CHEMBL1448503 | — | — | 1 | 4.71 |
| CHEMBL1519239 | — | — | 1 | 4.67 |
| CHEMBL1477954 | — | — | 1 | 4.60 |
| CHEMBL1488756 | — | — | 1 | 4.53 |
| CHEMBL1362935 | — | — | 1 | 4.52 |
| CHEMBL1986557 | — | — | 1 | 4.51 |
| CHEMBL1880983 | — | — | 1 | 4.48 |
| CHEMBL1458408 | — | — | 1 | 4.38 |
| CHEMBL1564441 | — | — | 1 | 4.33 |
| CHEMBL1874900 | — | — | 1 | 4.30 |
| CHEMBL1428817 | — | — | 1 | - |
| CHEMBL1418782 | — | — | 1 | - |
| CHEMBL1548517 | — | — | 1 | - |
| CHEMBL1541177 | — | — | 1 | - |
| CHEMBL1482044 | — | — | 1 | - |
| CHEMBL3190240 | — | — | 1 | - |
| CHEMBL1422155 | — | — | 1 | - |
| CHEMBL3190770 | — | — | 1 | - |
| CHEMBL1387761 | — | — | 1 | - |
| CHEMBL1451666 | — | — | 1 | - |
| CHEMBL3182668 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | IC50 | = | 11.47 | nM | 7.94 |
| CHEMBL67311 | — | IC50 | = | 3592.0 | nM | 5.45 |
| CHEMBL1898395 | — | IC50 | = | 3672.0 | nM | 5.43 |
| CHEMBL1527031 | — | IC50 | = | 3763.0 | nM | 5.42 |
| CHEMBL1329279 | — | IC50 | = | 5733.0 | nM | 5.24 |
| CHEMBL1605988 | — | IC50 | = | 10942.0 | nM | 4.96 |
| CHEMBL1494390 | — | IC50 | = | 11403.0 | nM | 4.94 |
| CHEMBL1503729 | — | IC50 | = | 17004.0 | nM | 4.77 |
| CHEMBL1896544 | — | IC50 | = | 18607.0 | nM | 4.73 |
| CHEMBL1448503 | — | IC50 | = | 19619.0 | nM | 4.71 |
| CHEMBL1519239 | — | IC50 | = | 21231.0 | nM | 4.67 |
| CHEMBL1477954 | — | IC50 | = | 24919.0 | nM | 4.60 |
| CHEMBL1488756 | — | IC50 | = | 29538.0 | nM | 4.53 |
| CHEMBL1362935 | — | IC50 | = | 30390.0 | nM | 4.52 |
| CHEMBL1986557 | — | IC50 | = | 31208.0 | nM | 4.51 |
| CHEMBL1880983 | — | IC50 | = | 32803.0 | nM | 4.48 |
| CHEMBL1458408 | — | IC50 | = | 41648.0 | nM | 4.38 |
| CHEMBL1564441 | — | IC50 | = | 46664.0 | nM | 4.33 |
| CHEMBL1874900 | — | IC50 | = | 50522.0 | nM | 4.30 |
| CHEMBL3190366 | — | IC50 | > | 69509.0 | nM | - |
| CHEMBL1610356 | — | IC50 | > | 69489.0 | nM | - |
| CHEMBL1536053 | — | IC50 | > | 69548.0 | nM | - |
| CHEMBL3192533 | — | IC50 | > | 69501.0 | nM | - |
| CHEMBL1894622 | — | IC50 | > | 69513.0 | nM | - |
| CHEMBL1586817 | — | IC50 | > | 69493.0 | nM | - |
| CHEMBL1534147 | — | IC50 | > | 69513.0 | nM | - |
| CHEMBL531709 | — | IC50 | > | 69541.0 | nM | - |
| CHEMBL1323869 | — | IC50 | > | 69459.0 | nM | - |
| CHEMBL1597320 | — | IC50 | > | 69520.0 | nM | - |
| CHEMBL2354591 | — | IC50 | > | 69583.0 | nM | - |
| CHEMBL1518330 | — | IC50 | > | 69511.0 | nM | - |
| CHEMBL1581141 | — | IC50 | > | 69520.0 | nM | - |
| CHEMBL1345528 | — | IC50 | > | 69497.0 | nM | - |
| CHEMBL1897629 | — | IC50 | > | 69555.0 | nM | - |
| CHEMBL1526021 | — | IC50 | > | 69520.0 | nM | - |
| CHEMBL1414034 | — | IC50 | > | 69490.0 | nM | - |
| CHEMBL3196877 | — | IC50 | > | 69510.0 | nM | - |
| CHEMBL1701083 | — | IC50 | > | 69506.0 | nM | - |
| CHEMBL1568525 | — | IC50 | > | 69501.0 | nM | - |
| CHEMBL1526184 | — | IC50 | > | 69509.0 | nM | - |
| CHEMBL1403216 | — | IC50 | > | 69512.0 | nM | - |
| CHEMBL1515214 | — | IC50 | > | 69520.0 | nM | - |
| CHEMBL1383732 | — | IC50 | > | 69513.0 | nM | - |
| CHEMBL2137206 | — | IC50 | > | 69217.0 | nM | - |
| CHEMBL3184916 | — | IC50 | > | 69448.0 | nM | - |
| CHEMBL1890635 | — | IC50 | > | 69499.0 | nM | - |
| CHEMBL1350803 | — | IC50 | > | 69497.0 | nM | - |
| CHEMBL1467369 | — | IC50 | > | 69487.0 | nM | - |
| CHEMBL1521021 | — | IC50 | > | 69513.0 | nM | - |
| CHEMBL1594922 | — | IC50 | > | 69501.0 | nM | - |