Assay Detail
Binding
CHEMBL3222371
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAM10 (unknown origin) using fluorescent substrate by fluorescence-based FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 10 (CHEMBL5028) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of -lactam hydroxamate based TACE inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.05 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489100 | — | — | 1 | 6.32 |
| CHEMBL3221863 | — | — | 1 | 5.92 |
| CHEMBL3221864 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489100 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3221863 | — | IC50 | = | 1211.0 | nM | 5.92 |
| CHEMBL3221864 | — | IC50 | = | 1199.0 | nM | 5.92 |