Assay Detail
Binding
CHEMBL3223058
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Inhibition of human cathepsin L1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel benzothiazole and triazole analogs as falcipain inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.50 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374508 | E-64 | — | 1 | 7.80 |
| CHEMBL3218765 | — | — | 1 | 5.36 |
| CHEMBL3218764 | — | — | 1 | 5.23 |
| CHEMBL3218778 | — | — | 1 | 4.61 |
| CHEMBL3218779 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374508 | E-64 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3218765 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL3218764 | — | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL3218778 | — | IC50 | = | 24390.0 | nM | 4.61 |
| CHEMBL3218779 | — | IC50 | = | 31630.0 | nM | 4.50 |