Assay Detail
Binding
CHEMBL3223602
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Inhibition of PI3Kbeta (unknown origin)
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecules targeting phosphoinositide 3-kinases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.38 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 7.57 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 7.48 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 7.36 |
| CHEMBL2064328 | — | — | 1 | 7.24 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.12 |
| CHEMBL3218574 | — | — | 1 | 6.96 |
| CHEMBL3349370 | — | — | 1 | 6.95 |
| CHEMBL1684984 | IZORLISIB | 2.0 | 1 | 6.92 |
| CHEMBL3218573 | — | — | 1 | 6.92 |
| CHEMBL3218572 | — | — | 1 | 6.89 |
| CHEMBL1233881 | — | — | 1 | 6.89 |
| CHEMBL1233882 | — | — | 1 | 6.62 |
| CHEMBL1241857 | — | — | 1 | 6.46 |
| CHEMBL3218575 | — | — | 1 | 6.42 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 6.25 |
| CHEMBL1229535 | — | — | 1 | 6.23 |
| CHEMBL3218580 | — | — | 1 | 6.13 |
| CHEMBL3218571 | — | — | 1 | 5.96 |
| CHEMBL1081312 | — | — | 1 | 5.85 |
| CHEMBL2181110 | — | — | 1 | 5.55 |
| CHEMBL478980 | — | — | 1 | 5.43 |
| CHEMBL1230790 | — | — | 1 | 5.07 |
| CHEMBL1234815 | — | — | 1 | 4.80 |
| CHEMBL1213082 | — | — | 1 | 4.12 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | - |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1922094 | APITOLISIB | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2064328 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3218574 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3349370 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1684984 | IZORLISIB | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3218573 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3218572 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1233881 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1233882 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1241857 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3218575 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 565.0 | nM | 6.25 |
| CHEMBL1229535 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3218580 | — | IC50 | = | 736.0 | nM | 6.13 |
| CHEMBL3218571 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1081312 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2181110 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL478980 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1230790 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1234815 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1213082 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL113 | CAFFEINE | IC50 | = | 400000.0 | nM | - |
| CHEMBL1355736 | THEOPHYLLINE | IC50 | = | 800000.0 | nM | - |