Assay Detail
Binding
CHEMBL3223604
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Inhibition of PI3Kgamma (unknown origin)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecules targeting phosphoinositide 3-kinases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.42 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 8.30 |
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 8.27 |
| CHEMBL3349370 | — | — | 1 | 8.05 |
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 7.85 |
| CHEMBL1229535 | — | — | 1 | 7.80 |
| CHEMBL3218575 | — | — | 1 | 7.64 |
| CHEMBL1684984 | IZORLISIB | 2.0 | 1 | 7.44 |
| CHEMBL1233882 | — | — | 1 | 7.37 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 7.31 |
| CHEMBL3218571 | — | — | 1 | 7.27 |
| CHEMBL1233881 | — | — | 1 | 7.14 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 7.12 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 7.05 |
| CHEMBL1241857 | — | — | 1 | 6.75 |
| CHEMBL1234815 | — | — | 1 | 6.24 |
| CHEMBL1081312 | — | — | 1 | 5.96 |
| CHEMBL1230790 | — | — | 1 | 5.82 |
| CHEMBL3218580 | — | — | 1 | 5.75 |
| CHEMBL2064328 | — | — | 1 | 5.39 |
| CHEMBL3218573 | — | — | 1 | 5.00 |
| CHEMBL1213082 | — | — | 1 | 4.54 |
| CHEMBL2181110 | — | — | 1 | 4.43 |
| CHEMBL478980 | — | — | 1 | 4.00 |
| CHEMBL3218572 | — | — | 1 | 4.00 |
| CHEMBL3218574 | — | — | 1 | 4.00 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | - |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL3349370 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1922094 | APITOLISIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1229535 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3218575 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1684984 | IZORLISIB | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1233882 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3218571 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1233881 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1241857 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1234815 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1081312 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1230790 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3218580 | — | IC50 | = | 1774.0 | nM | 5.75 |
| CHEMBL2064328 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3218573 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1213082 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2181110 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL478980 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3218572 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3218574 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1355736 | THEOPHYLLINE | IC50 | = | 800000.0 | nM | - |
| CHEMBL113 | CAFFEINE | IC50 | = | 1000000.0 | nM | - |