Assay Detail
Binding
CHEMBL3223610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin)
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecules targeting phosphoinositide 3-kinases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.61 | 8.80 |
| Ki | 2 | 7.79 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 8.80 |
| CHEMBL1081312 | — | — | 1 | 8.00 |
| CHEMBL3218579 | — | — | 1 | 7.80 |
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 7.77 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.68 |
| CHEMBL1233882 | — | — | 1 | 6.85 |
| CHEMBL3349370 | — | — | 1 | 6.72 |
| CHEMBL3218580 | — | — | 1 | 5.97 |
| CHEMBL1233881 | — | — | 1 | 5.77 |
| CHEMBL1230790 | — | — | 1 | 5.68 |
| CHEMBL1234815 | — | — | 1 | 4.00 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1081312 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3218579 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1922094 | APITOLISIB | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1233882 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3349370 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3218580 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL1233881 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1230790 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1234815 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2216870 | IDELALISIB | IC50 | > | 10000.0 | nM | - |