Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3223663

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human cathepsin L
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Procathepsin L (CHEMBL3837)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Peptidomimetic nitriles as selective inhibitors for the malarial cysteine protease falcipain-2
Ehmke V, Kilchmann F, Heindl C, Cui K, Huang J, Schirmeister T, Diederich F
Medchemcomm (2011) 2 : 800 -804
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 4.94 6.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3218476 1 6.09
CHEMBL3218473 1 4.88
CHEMBL3218467 1 4.60
CHEMBL200151 1 4.58
CHEMBL3218471 1 4.53
CHEMBL3218465 1 -
CHEMBL3218466 1 -
CHEMBL3218468 1 -
CHEMBL3218469 1 -
CHEMBL3218470 1 -
CHEMBL3218472 1 -
CHEMBL3218474 1 -
CHEMBL3218475 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3218476 Ki = 820.0 nM 6.09
CHEMBL3218473 Ki = 13100.0 nM 4.88
CHEMBL3218467 Ki = 25100.0 nM 4.60
CHEMBL200151 Ki = 26500.0 nM 4.58
CHEMBL3218471 Ki = 29800.0 nM 4.53
CHEMBL3218465 Ki - -
CHEMBL3218466 Ki - -
CHEMBL3218468 Ki - -
CHEMBL3218469 Ki - -
CHEMBL3218470 Ki - -
CHEMBL3218472 Ki - -
CHEMBL3218474 Ki - -
CHEMBL3218475 Ki - -