Assay Detail
Functional
CHEMBL3223699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCC827 cells expressing EGFR kinase E746 to A750 deletion mutant after 72 hrs by MTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of new molecules inhibiting epidermal growth factor receptor threonine790 methionine790 mutant
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.70 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229592 | — | — | 1 | 7.62 |
| CHEMBL3219133 | — | — | 1 | 7.62 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.39 |
| CHEMBL3219127 | — | — | 1 | 7.17 |
| CHEMBL3219129 | — | — | 1 | 7.16 |
| CHEMBL3219347 | — | — | 1 | 7.15 |
| CHEMBL3219348 | — | — | 1 | 7.06 |
| CHEMBL3219128 | — | — | 1 | 6.89 |
| CHEMBL3219132 | — | — | 1 | 6.85 |
| CHEMBL3219134 | — | — | 1 | 6.55 |
| CHEMBL3219135 | — | — | 1 | 6.52 |
| CHEMBL3219130 | — | — | 1 | 6.22 |
| CHEMBL3219125 | — | — | 1 | 5.78 |
| CHEMBL3219131 | — | — | 1 | 5.42 |
| CHEMBL3219126 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229592 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3219133 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL939 | GEFITINIB | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3219127 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3219129 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3219347 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3219348 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3219128 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3219132 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3219134 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3219135 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3219130 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3219125 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL3219131 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL3219126 | — | IC50 | = | 6900.0 | nM | 5.16 |