Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3223836

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifungal activity against Cryptococcus neoformans ATCC 90113 assessed as growth inhibition after 70 to 74 hrs by modified CLSI method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cryptococcus neoformans
Confidence 1 — Organism
Curated By Autocuration

Target

Cryptococcus neoformans (CHEMBL365)
Type ORGANISM
Organism Cryptococcus neoformans

Publication

Synthesis and biological activity profile of novel 2-cinnamylidene-1,3-diones related to coruscanone A: promising new antileishmanial agents
Riveira MJ, Tekwani BL, Labadie GR, Mischne MP
Medchemcomm (2012) 3 : 1294 -1298
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.82 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.46
CHEMBL216028 CORUSCANONE A 1 5.10
CHEMBL3220298 1 4.93
CHEMBL3220516 1 4.93
CHEMBL3220518 1 4.87
CHEMBL3220306 1 4.84
CHEMBL3220303 1 4.78
CHEMBL3220301 1 4.72
CHEMBL3220515 1 4.70
CHEMBL3217782 1 4.63
CHEMBL3220302 1 4.61
CHEMBL3220517 1 4.57
CHEMBL3220297 1 4.45
CHEMBL3220304 1 4.42
CHEMBL3220307 1 4.35
CHEMBL3220308 1 -
CHEMBL3220514 1 -
CHEMBL3220305 1 -
CHEMBL3220300 1 -
CHEMBL3220299 1 -
CHEMBL3220296 1 -
CHEMBL55 PENTAMIDINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267345 AMPHOTERICIN B IC50 = 350.0 nM 6.46
CHEMBL216028 CORUSCANONE A IC50 = 8020.0 nM 5.10
CHEMBL3220298 IC50 = 11690.0 nM 4.93
CHEMBL3220516 IC50 = 11870.0 nM 4.93
CHEMBL3220518 IC50 = 13370.0 nM 4.87
CHEMBL3220306 IC50 = 14450.0 nM 4.84
CHEMBL3220303 IC50 = 16630.0 nM 4.78
CHEMBL3220301 IC50 = 19030.0 nM 4.72
CHEMBL3220515 IC50 = 19890.0 nM 4.70
CHEMBL3217782 IC50 = 23600.0 nM 4.63
CHEMBL3220302 IC50 = 24730.0 nM 4.61
CHEMBL3220517 IC50 = 26860.0 nM 4.57
CHEMBL3220297 IC50 = 35300.0 nM 4.45
CHEMBL3220304 IC50 = 38220.0 nM 4.42
CHEMBL3220307 IC50 = 44710.0 nM 4.35
CHEMBL3220308 IC50 > 60000.0 nM -
CHEMBL3220514 IC50 > 60000.0 nM -
CHEMBL3220305 IC50 > 60000.0 nM -
CHEMBL3220300 IC50 > 60000.0 nM -
CHEMBL3220299 IC50 > 60000.0 nM -
CHEMBL3220296 IC50 > 60000.0 nM -
CHEMBL55 PENTAMIDINE IC50 - -