Assay Detail
Functional
CHEMBL3223837
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against Leishmania donovani S1 promastigotes assessed as growth inhibition after 72 hrs by alamar blue assay
44
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity profile of novel 2-cinnamylidene-1,3-diones related to coruscanone A: promising new antileishmanial agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.95 | 6.51 |
| IC90 | 22 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 2 | 6.51 |
| CHEMBL3220516 | — | — | 2 | 5.67 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 2 | 5.42 |
| CHEMBL3220518 | — | — | 2 | 5.15 |
| CHEMBL3220514 | — | — | 2 | 5.12 |
| CHEMBL3220517 | — | — | 2 | 5.07 |
| CHEMBL3220297 | — | — | 2 | 5.03 |
| CHEMBL3217782 | — | — | 2 | 5.03 |
| CHEMBL3220302 | — | — | 2 | 5.02 |
| CHEMBL3220298 | — | — | 2 | 5.02 |
| CHEMBL3220306 | — | — | 2 | 4.99 |
| CHEMBL3220303 | — | — | 2 | 4.97 |
| CHEMBL3220515 | — | — | 2 | 4.93 |
| CHEMBL3220296 | — | — | 2 | 4.72 |
| CHEMBL3220307 | — | — | 2 | 4.71 |
| CHEMBL3220301 | — | — | 2 | 4.70 |
| CHEMBL3220304 | — | — | 2 | 4.51 |
| CHEMBL3220299 | — | — | 2 | 4.42 |
| CHEMBL3220305 | — | — | 2 | 4.34 |
| CHEMBL3220300 | — | — | 2 | 4.33 |
| CHEMBL3220308 | — | — | 2 | 4.25 |
| CHEMBL216028 | CORUSCANONE A | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3220516 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL3220518 | — | IC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL3220514 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL3220517 | — | IC50 | = | 8580.0 | nM | 5.07 |
| CHEMBL3220297 | — | IC50 | = | 9290.0 | nM | 5.03 |
| CHEMBL3217782 | — | IC50 | = | 9380.0 | nM | 5.03 |
| CHEMBL3220298 | — | IC50 | = | 9550.0 | nM | 5.02 |
| CHEMBL3220302 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL3220306 | — | IC50 | = | 10250.0 | nM | 4.99 |
| CHEMBL3220303 | — | IC50 | = | 10650.0 | nM | 4.97 |
| CHEMBL3220515 | — | IC50 | = | 11790.0 | nM | 4.93 |
| CHEMBL3220296 | — | IC50 | = | 19130.0 | nM | 4.72 |
| CHEMBL3220307 | — | IC50 | = | 19510.0 | nM | 4.71 |
| CHEMBL3220301 | — | IC50 | = | 20050.0 | nM | 4.70 |
| CHEMBL3220304 | — | IC50 | = | 30590.0 | nM | 4.51 |
| CHEMBL3220299 | — | IC50 | = | 38470.0 | nM | 4.42 |
| CHEMBL3220305 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL3220300 | — | IC50 | = | 46640.0 | nM | 4.33 |
| CHEMBL3220308 | — | IC50 | = | 56780.0 | nM | 4.25 |
| CHEMBL216028 | CORUSCANONE A | IC50 | - | — | - | |
| CHEMBL3220296 | — | IC90 | = | 52260.0 | nM | - |
| CHEMBL3220297 | — | IC90 | = | 66110.0 | nM | - |
| CHEMBL3220298 | — | IC90 | = | 24550.0 | nM | - |
| CHEMBL3220299 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3220300 | — | IC90 | = | 99150.0 | nM | - |
| CHEMBL3220301 | — | IC90 | = | 27520.0 | nM | - |
| CHEMBL3217782 | — | IC90 | = | 26630.0 | nM | - |
| CHEMBL3220302 | — | IC90 | = | 18600.0 | nM | - |
| CHEMBL3220303 | — | IC90 | = | 24970.0 | nM | - |
| CHEMBL3220304 | — | IC90 | = | 68930.0 | nM | - |
| CHEMBL3220305 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL55 | PENTAMIDINE | IC90 | = | 12400.0 | nM | - |
| CHEMBL267345 | AMPHOTERICIN B | IC90 | = | 1090.0 | nM | - |
| CHEMBL216028 | CORUSCANONE A | IC90 | - | — | - | |
| CHEMBL3220518 | — | IC90 | = | 19810.0 | nM | - |
| CHEMBL3220517 | — | IC90 | = | 14080.0 | nM | - |
| CHEMBL3220516 | — | IC90 | = | 3580.0 | nM | - |
| CHEMBL3220515 | — | IC90 | = | 20050.0 | nM | - |
| CHEMBL3220514 | — | IC90 | = | 14740.0 | nM | - |
| CHEMBL3220308 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3220307 | — | IC90 | = | 91690.0 | nM | - |
| CHEMBL3220306 | — | IC90 | = | 26120.0 | nM | - |