Assay Detail
Binding
CHEMBL3224129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GGTase1 in human Burkitt lymphoma (Daudi) cell supernatant using [3H]geranylgeranyl
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Geranylgeranyl transferase type I (CHEMBL2095164) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.49 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282103 | — | — | 1 | 8.30 |
| CHEMBL3218390 | GGTI-2418 | 1.0 | 1 | 8.02 |
| CHEMBL3218391 | — | — | 1 | 7.68 |
| CHEMBL3218393 | — | — | 1 | 7.30 |
| CHEMBL54044 | — | — | 1 | 7.30 |
| CHEMBL3218389 | — | — | 1 | 6.33 |
| CHEMBL279433 | L-778123 FREE BASE | 1.0 | 1 | - |
| CHEMBL3218388 | — | — | 1 | - |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | - |
| CHEMBL2171679 | — | — | 1 | - |
| CHEMBL1738728 | — | — | 1 | - |
| CHEMBL298734 | LONAFARNIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282103 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3218390 | GGTI-2418 | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL3218391 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3218393 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL54044 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3218389 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL279433 | L-778123 FREE BASE | IC50 | = | 98.0 | nM | - |
| CHEMBL3218388 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL289228 | TIPIFARNIB | IC50 | > | 50000.0 | nM | - |
| CHEMBL2171679 | — | IC50 | > | 99500.0 | nM | - |
| CHEMBL1738728 | — | IC50 | > | 99500.0 | nM | - |
| CHEMBL298734 | LONAFARNIB | IC50 | > | 50000.0 | nM | - |