Geranylgeranyl transferase type I · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P49354. Use UniProt P49354 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49354 as the stable identity anchor, then attach disease evidence before program review.
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Geranylgeranyl transferase type I, mapped to UniProt P49354. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 379 aa.
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This review treats Geranylgeranyl transferase type I as ChEMBL target CHEMBL2095164, mapped to UniProt P49354. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Geranylgeranyl transferase type I |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P49354 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| UniProt Accession | P49354 |
| Component Type | Protein |
| Sequence Length | 379 aa |
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Geranylgeranyl transferase type I, mapped to UniProt P49354. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 379 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL64183 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL424564 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL63107 | 9.49 | IC50 | 0.32 | Preclinical |
| CHEMBL63106 | 9.49 | IC50 | 0.32 | Preclinical |
| CHEMBL291580 | 9.17 | IC50 | 0.68 | Preclinical |
| CHEMBL322435 | 9.09 | IC50 | 0.81 | Preclinical |
| CHEMBL303326 | 9.08 | IC50 | 0.84 | Preclinical |
| CHEMBL75804 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL99901 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL159171 | 8.77 | IC50 | 1.7 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 72 | 406 | 6.1 |
| assay format | 14 | 30 | 6.0 |
| cell-based format | 12 | 1 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 14 | 19 | 6.1 |
| assay format | 3 | 42 | 6.3 |