Compound Detail
CHEMBL424564
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Basic Information
| ChEMBL ID | CHEMBL424564 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQNYIQPZXRNJMG-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
458.6
MW (Da)
3.60
ALogP
5
HBA
1
HBD
77.2
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Geranylgeranyl transferase type I CHEMBL2095164 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 6.29 | 6.29 | 517.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Geranylgeranyl transferase type I | IC50 | = | 0.2 | nM | 9.7 | Inhibitory activity against human Geranylgeranyl transferase type I | 11294379 |
| Protein farnesyltransferase | IC50 | = | 517.0 | nM | 6.29 | Concentration required for the inhibitory activity against human Farnesyltransfe... | 11294379 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11294379 | 10.1016/s0960-894x(01)00061-0 | Protein farnesyltransferase | 1 |
| 11294379 | 10.1016/s0960-894x(01)00061-0 | Geranylgeranyl transferase type I | 1 |
Data from ChEMBL 36 via Core Engine