Assay Detail
Functional
CHEMBL3224281
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Vasorelaxant activity in Sprague-Dawley rat thoracic aorta with intact endothelium assessed as inhibition of Ca2+-induced contraction after 20 mins
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Water soluble flavonol prodrugs that protect against ischaemia-reperfusion injury in rat hindlimb and sheep heart
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.11 | 5.37 |
| Rmax | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294009 | FLAVONOL | — | 2 | 5.37 |
| CHEMBL122701 | — | — | 2 | 5.02 |
| CHEMBL272682 | — | — | 2 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294009 | FLAVONOL | IC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL122701 | — | IC50 | = | 9549.93 | nM | 5.02 |
| CHEMBL272682 | — | IC50 | = | 11748.98 | nM | 4.93 |
| CHEMBL294009 | FLAVONOL | Rmax | = | 19.0 | % | - |
| CHEMBL272682 | — | Rmax | = | 70.0 | % | - |
| CHEMBL122701 | — | Rmax | = | 89.0 | % | - |