Assay Detail
Functional
CHEMBL3224508
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Antiviral activity against Influenza A virus (A/Sydney/5/1997(H3N2)) infected in MDCK cells assessed as reduction of virus-induced cytopathic effect after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Sydney/5/1997(H3N2)) |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.40 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3218395 | — | — | 1 | 9.21 |
| CHEMBL3218394 | — | — | 1 | 9.14 |
| CHEMBL3218397 | — | — | 1 | 9.10 |
| CHEMBL3218396 | — | — | 1 | 8.87 |
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 7.01 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 6.11 |
| CHEMBL3218399 | — | — | 1 | 5.89 |
| CHEMBL3218400 | — | — | 1 | 5.74 |
| CHEMBL3218398 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3218395 | — | EC50 | = | 0.61 | nM | 9.21 |
| CHEMBL3218394 | — | EC50 | = | 0.73 | nM | 9.14 |
| CHEMBL3218397 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3218396 | — | EC50 | = | 1.36 | nM | 8.87 |
| CHEMBL1229 | OSELTAMIVIR | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 786.0 | nM | 6.11 |
| CHEMBL3218399 | — | EC50 | = | 1285.0 | nM | 5.89 |
| CHEMBL3218400 | — | EC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL3218398 | — | EC50 | = | 3005.0 | nM | 5.52 |