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Assay Detail

CHEMBL3224672

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP1A1 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytochrome P450 1A1 (CHEMBL2231)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

trans-Stilbenoids: potent and selective inhibitors for human cytochrome P450 1B1
Chun Y, Lim C, Ohk SO, Lee JM, Lee JH, Choi S, Kim S
Medchemcomm (2011) 2 : 402 -405
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 3 6.65 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL498917 1 6.92
CHEMBL291501 RESVERATROL 4'-METHYL ETHER 1 6.80
CHEMBL83527 PTEROSTILBENE 2.0 1 6.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL498917 Ki = 120.0 nM 6.92
CHEMBL291501 RESVERATROL 4'-METHYL ETHER Ki = 160.0 nM 6.80
CHEMBL83527 PTEROSTILBENE Ki = 570.0 nM 6.24