Assay Detail
Binding
CHEMBL3224673
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Inhibition of human CYP1B1 expressed in Escherichia coli assessed as changes in ethoxyresorufin O-deethylation activity after 3 mins by spectrofluorometer analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
trans-Stilbenoids: potent and selective inhibitors for human cytochrome P450 1B1
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.60 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220148 | — | — | 1 | 7.11 |
| CHEMBL3220143 | — | — | 1 | 7.01 |
| CHEMBL3220149 | — | — | 1 | 6.83 |
| CHEMBL3132926 | — | — | 1 | 6.72 |
| CHEMBL3220146 | — | — | 1 | 6.72 |
| CHEMBL3220145 | — | — | 1 | 6.65 |
| CHEMBL46909 | — | — | 1 | 6.52 |
| CHEMBL3220147 | — | — | 1 | 6.52 |
| CHEMBL2043279 | — | — | 1 | 6.47 |
| CHEMBL3220144 | — | — | 1 | 6.46 |
| CHEMBL3132932 | — | — | 1 | 6.46 |
| CHEMBL3220150 | — | — | 1 | 6.38 |
| CHEMBL3219852 | — | — | 1 | 6.31 |
| CHEMBL242396 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220148 | — | IC50 | = | 78.4 | nM | 7.11 |
| CHEMBL3220143 | — | IC50 | = | 98.2 | nM | 7.01 |
| CHEMBL3220149 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL3132926 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3220146 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL3220145 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL46909 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3220147 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL2043279 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL3220144 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3132932 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3220150 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3219852 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL242396 | — | IC50 | = | 666.0 | nM | 6.18 |