Assay Detail
Binding
CHEMBL3224718
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Inhibition of Ca2+-dependent activation of porcine calpain-1 using SucLY-AMC as substrate
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent inhibition of Ca2+-dependent activation of calpain-1 by novel mercaptoacrylates
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.01 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3221938 | — | — | 1 | 7.70 |
| CHEMBL3221937 | — | — | 1 | 7.30 |
| CHEMBL3221946 | — | — | 1 | 7.16 |
| CHEMBL3221945 | — | — | 1 | 7.05 |
| CHEMBL3221942 | — | — | 1 | 7.05 |
| CHEMBL3221939 | — | — | 1 | 7.05 |
| CHEMBL3221941 | — | — | 1 | 7.00 |
| CHEMBL3221935 | — | — | 1 | 7.00 |
| CHEMBL3221944 | — | — | 1 | 6.96 |
| CHEMBL3221934 | — | — | 1 | 6.85 |
| CHEMBL3221947 | — | — | 1 | 6.66 |
| CHEMBL3221943 | — | — | 1 | 6.52 |
| CHEMBL3221940 | — | — | 1 | 6.52 |
| CHEMBL3221933 | — | — | 1 | 6.52 |
| CHEMBL3221936 | — | — | 1 | 6.03 |
| CHEMBL3221932 | — | — | 1 | 5.82 |
| CHEMBL366254 | — | — | 1 | 5.28 |
| CHEMBL3221930 | — | — | 1 | 5.25 |
| CHEMBL3221928 | — | — | 1 | 5.08 |
| CHEMBL3221924 | — | — | 1 | 5.04 |
| CHEMBL3221927 | — | — | 1 | 4.88 |
| CHEMBL3221931 | — | — | 1 | 4.82 |
| CHEMBL3221923 | — | — | 1 | 4.68 |
| CHEMBL3221922 | — | — | 1 | 4.63 |
| CHEMBL3221929 | — | — | 1 | 4.62 |
| CHEMBL3221926 | — | — | 1 | 4.50 |
| CHEMBL3221925 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3221938 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3221937 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3221946 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3221945 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3221942 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3221939 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3221941 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3221935 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3221944 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3221934 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3221947 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3221943 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3221940 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3221933 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3221936 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL3221932 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL366254 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3221930 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3221928 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3221924 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3221927 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL3221931 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3221923 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL3221922 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL3221929 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL3221926 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL3221925 | — | IC50 | = | 42800.0 | nM | 4.37 |