Assay Detail
Binding
CHEMBL3225092
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Inhibition of matriptase-2 (unknown origin) expressed in HEK293 cells using ln-Ala-Arg-a-Arg-para-nitroanilide as substrate by UV-vis spectrophotometry
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New 3-amidinophenylalanine-derived inhibitors of matriptase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 5.98 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3219101 | — | — | 1 | 7.14 |
| CHEMBL3219079 | — | — | 1 | 6.96 |
| CHEMBL3219100 | — | — | 1 | 6.75 |
| CHEMBL3219081 | — | — | 1 | 6.68 |
| CHEMBL3219087 | — | — | 1 | 6.51 |
| CHEMBL3219078 | — | — | 1 | 6.46 |
| CHEMBL3219085 | — | — | 1 | 6.40 |
| CHEMBL3219092 | — | — | 1 | 6.34 |
| CHEMBL3219083 | — | — | 1 | 6.24 |
| CHEMBL3219080 | — | — | 1 | 6.12 |
| CHEMBL3219086 | — | — | 1 | 6.11 |
| CHEMBL3219097 | — | — | 1 | 6.10 |
| CHEMBL3219103 | — | — | 1 | 6.03 |
| CHEMBL3219099 | — | — | 1 | 5.96 |
| CHEMBL3219090 | — | — | 1 | 5.92 |
| CHEMBL3219091 | — | — | 1 | 5.89 |
| CHEMBL3219084 | — | — | 1 | 5.89 |
| CHEMBL3219098 | — | — | 1 | 5.89 |
| CHEMBL3219095 | — | — | 1 | 5.89 |
| CHEMBL3219102 | — | — | 1 | 5.85 |
| CHEMBL3219082 | — | — | 1 | 5.80 |
| CHEMBL3219096 | — | — | 1 | 5.75 |
| CHEMBL3219094 | — | — | 1 | 5.72 |
| CHEMBL3219073 | — | — | 1 | 5.68 |
| CHEMBL3219093 | — | — | 1 | 5.62 |
| CHEMBL3219072 | — | — | 1 | 5.52 |
| CHEMBL3219077 | — | — | 1 | 5.50 |
| CHEMBL3219075 | — | — | 1 | 5.50 |
| CHEMBL3219088 | — | — | 1 | 5.48 |
| CHEMBL3219089 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3219101 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL3219079 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3219100 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3219081 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3219087 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL3219078 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL3219085 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL3219092 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL3219083 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL3219080 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL3219086 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL3219097 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL3219103 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL3219099 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3219090 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3219084 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3219095 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3219098 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3219091 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3219102 | — | Ki | = | 1420.0 | nM | 5.85 |
| CHEMBL3219082 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3219096 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3219094 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL3219073 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL3219093 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL3219072 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL3219077 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL3219075 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL3219088 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL3219089 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL3219076 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL3219074 | — | Ki | = | 10000.0 | nM | 5.00 |