Assay Detail
Binding
CHEMBL3225200
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse recombinant PARP2 assessed as radioactivity incorporated from [adenine-2,8-3H]NAD into proteins by liquid scintillation spectrometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.72 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3219283 | — | — | 1 | 7.42 |
| CHEMBL3219282 | — | — | 1 | 6.52 |
| CHEMBL3108871 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3219283 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3219282 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3108871 | — | IC50 | = | 600.0 | nM | 6.22 |