Assay Detail
Binding
CHEMBL3226834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Sirt2 using ZMAL as substrate after 4 hrs by fluorescent deacetylase assay
28
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NAD+dependent histone deacetylase Sirt2
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.44 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200850 | — | — | 2 | 5.82 |
| CHEMBL3220457 | — | — | 2 | 5.75 |
| CHEMBL3220461 | — | — | 2 | 5.66 |
| CHEMBL200192 | — | — | 2 | 5.66 |
| CHEMBL3220459 | — | — | 2 | 5.58 |
| CHEMBL2203548 | — | — | 2 | 5.55 |
| CHEMBL3220463 | — | — | 2 | 5.46 |
| CHEMBL3220462 | — | — | 2 | 5.42 |
| CHEMBL3220458 | — | — | 2 | 5.41 |
| CHEMBL3220456 | — | — | 2 | 5.31 |
| CHEMBL3220460 | — | — | 2 | 5.26 |
| CHEMBL3220454 | — | — | 2 | 5.24 |
| CHEMBL3220455 | — | — | 2 | 5.24 |
| CHEMBL3220464 | — | — | 2 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200850 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL200850 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL3220457 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3220457 | — | IC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL200192 | — | IC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL3220461 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3220459 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3220459 | — | IC50 | = | 2630.27 | nM | 5.58 |
| CHEMBL2203548 | — | IC50 | = | 2818.38 | nM | 5.55 |
| CHEMBL2203548 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3220463 | — | IC50 | = | 3467.37 | nM | 5.46 |
| CHEMBL3220463 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3220462 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3220462 | — | IC50 | = | 3801.89 | nM | 5.42 |
| CHEMBL3220458 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3220458 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL3220456 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3220456 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL3220460 | — | IC50 | = | 5495.41 | nM | 5.26 |
| CHEMBL3220460 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3220464 | — | IC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL3220455 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3220464 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3220454 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3220455 | — | IC50 | = | 5888.44 | nM | 5.23 |
| CHEMBL3220454 | — | IC50 | = | 5888.44 | nM | 5.23 |
| CHEMBL3220461 | — | IC50 | = | 6456.54 | nM | 5.19 |
| CHEMBL200192 | — | IC50 | = | 6500.0 | nM | 5.19 |